Evolution of vaccine development against pneumococcal pneumonia

Evolution of vaccine development against pneumococcal pneumonia.
-The word limit is 4000-6000 words.
-Provide me or send to me all references that you will use in my paper because I need the abstract for each reference you will use.
-Table of content is needed.
These are the organization and outlines for the assignment:
– Abstract.
• Introduction to the topic:
• Background information about pneumococcal pneumonia infection:
• The causative agent
• Disease syndromes caused by it.
• Characteristics of the diseases.
• Manifestations of the disease.
• Diagnosis and the current therapeutic strategies of the disease.
• Epidemiology including the spread, worldwide incidence, prevalence, pandemic, significance to the public health and the economic cost.
• Source and reservoir+ incubation period.
• Modes of the transmission of the pathogen.
• Mechanisms of pathogenesis:
• Virulence factors and those that need attention in vaccine development.
• Risk factors.
• People at risk.
• Evolution of vaccine development against pneumococcal infection:
• Immunization and prophylaxis against pneumonia.
• Serotype diversity.
• The specificity of immune response against serotypes.
• Types of vaccines undergoing trials.
• Immunization schedule.
• Current vaccines undergoing trials.
• Their benefits and limitations.
• The novel alternatives for third generation pneumococcal vaccines.
• Burden and cost effectiveness of vaccination.
• Current status of the development of improved vaccines and the ways by which the improved vaccines will be better than the currently used vaccines.
• Discussion:- Indicate all of previous different evolutions.
• Conclusion + future directions for vaccine development.